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The role of mtDNA in oocyte quality and embryo development

The central question is not simply Is methylation low? It is: Is the dominant problem inadequate SAM production, excessive SAH inhibition, or a combination of both

8.4 Pediatric Use The safety and effectiveness of BASAGLAR have been established in pediatric patients (age 6 to 15 years) with type 1 diabetes based on an adequate and well-controlled trial of another insulin glargine product, 100 units/mL, in pediatric patients (age 6 to 15 years) with type 1 diabetes and additional data in adults with type 1 diabetes [see Clinical Studies (14.2)]