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Multiple studies have demonstrated that consistent administration of HCQ and CQ during the first five years of the disease improves treatment outcomes, whether used as monotherapy or in combination with other therapies (104)

Following the semi qualitative assessment, the ROS levels were quantified by flow cytometry

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All clinical activities were conducted at the Centre Hospitalier Bretagne Sud (Lorient, France), in accordance with the Helsinki Declaration, the French Public Health Code concerning the biomedical researches and the rules of Clinical Best Practice