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dual product use may be worse Two related studies, one in humans and the other in rats, found that the cardiovascular effects of cigarettes and e-cigarettes are strikingly similar, and these harmful effects on blood vessel function are likely caused by airway irritation due to inhalation of a foreign substance, rather than a specific component of the cigarette smoke or e-cigarette vapor (aerosol)

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Studies highlight fewer combustion toxins but still identify IQOS respiratory risks , including airway irritation and potential IQOS lung damage with long-term use

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