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While a small PDA is usually asymptomatic, a large PDA with significant left to right shunt may lead to CHF and eventually pulmonary hypertension

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Since the medication distributes into your bloodstream over hours and works for seven days, injecting before bed allows you to sleep through any early nausea while maintaining full weekly efficacy

Heart Fail Rev (2008) 13:32137 10.1007/s10741-007-9062-x [DOI] [PubMed] [Google Scholar] 146.Stragier B, Sarre S, Vanderheyden P, Vauquelin G, Fournie-Zaluski MC, Ebinger G, et al