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A multicenter randomized study demonstrated that carvedilol (a non-selective -blocker with intrinsic anti-1 activity) combined with simvastatin reduced HVPG by 18.9% versus 12.5% with carvedilol alone in cirrhosis patients with suboptimal response to traditional -blockers, concurrently attenuating postprandial endothelial dysfunction and proinflammatory cytokines (IL-6, MCP-1) 75

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118 A recent study in a rodent spinal cord injury model showed that liraglutide puts the brakes on microglial pyroptosis, a specific type of inflammatory cell death, through the GLP-1 receptor mediated PI3K/Akt/TFEB/FANCC/p38 signaling pathway

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