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The usual GI side effects mean that patient education and monitoring are key for the best safety and adherence

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In the SURPASS 1-5 trials, different dosages of Tirzepatide (5 mg, 10 mg, and 15 mg) demonstrated significant weight reduction in obese patients with type 2 diabetes mellitus (T2DM), especially when compared to placebo (SURPASS 1) (25), semaglutide 1 mg (SURPASS 2) (26), insulin degludec (SURPASS 3) (27), insulin glargine (SURPASS 4) (28), and placebo+ insulin glargine (SURPASS 5) (29)

in the lungs, they alleviate acute respiratory distress syndrome (ARDS) by reducing cytokine production, stimulating surfactant secretion, and preserving alveolar-capillary barrier