However, during ovarian aging, defects in PINK1/Parkin-mediated mitophagy further promote ferroptosis and apoptosis (Khan et al., 2023
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Cell 126(4):677689 Ericson J, Muhr J, Placzek M, Lints T, Jessell TM, Edlund T (1995) Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube
Taken together, the human imaging and animal data are most consistent with plaque stabilization rather than gross atheroma regression, though the causal mechanism remains an inference rather than a directly proven pathway
