"Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children." Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association , 2017
Effective pharmacotherapy for obesity is likely to require long-term, if not life-long, treatment, which makes it important to consider long-term adherence and weight loss efficacy, and the effects on obesity co-morbidities (particularly cardiovascular outcomes), safety (including potential adverse effects on muscle mass and bone health), and cost of poly-agonist therapy
High-risk patients require comprehensive evaluation including liquid diet protocols, prokinetic agent consideration, and potential procedure delay [57]
The molecular mechanism of kidney diseases mediated by microbial dysbiosis and the renal protective effect of gut microecological preparations