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It plays a crucial role in energy production and the efficient metabolism of fatty acids and amino acids

Given that cellular senescence is now recognized as one of the primary pillars of biological aging, this third mechanism elevates MOTS-c from a metabolic peptide to a potential geroscience intervention

Because MOTS-c enhances insulin-independent glucose uptake, patients with type 1 diabetes or those using exogenous insulin should be monitored carefully to prevent hypoglycemia, though this theoretical risk has not materialized in clinical reports to date