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Increased ROS levels trigger the upregulation of various antioxidant proproteins/enzymes, initiating a negative feedback mechanism to modulate stress signaling or ROS concentrations

While we are disappointed to discontinue the development of danuglipron, we remain committed to evaluating and advancing promising programs in an effort to bring innovative new medicines to patients, Chris Boshoff, chief scientific officer at Pizer, said in a statement

10.1046/j.1365-201x.2003.01093.x 20 Guerrero-OchoaP.Aguilar-MachadoD.Ibez-PrezR.Macas-LenJ.Hurtado-GuerreroR.RasoJ.et al (2020)

The antioxidant properties of SOD1 and its relationship to neurodegeneration have been extensively studied in ALS (Proescher et al., 2008