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Nicotine in e-cigarettes can induce dysfunction in the cystic fibrosis transmembrane conductance regulator (CFTR), delaying ciliary clearance and impairing mucociliary defense function [43]

The crude OR of developing vitamin B12 deficiency of undetermined origin in type 2 diabetic patients on metformin compared with diabetic patients not on metformin was 4.50 (95% CI, 2.30 - 8.82)

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But quitting is notoriously difficult: its estimated that 80% of people who smoke have tried to quit, and struggled