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But hepatic insulin resistance occurs in some pathologic states, such as obesity and type 2 diabetes, which leads to an increase of hepatic glucose production and lipid synthesis ( In high-fructose-fed rats, treatment of SFN showed comparable improvements of insulin resistance and hepatoprotective effect when compared to the standard insulin sensitizer pioglitazone (Tian et al., 2021a

Forty percent of our business is in emerging markets where I dont think GLP-1s will be embraced