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Public Health 230:223230 Gravely S, Cummings KM, Hammond D, Lindblom E, Smith DM, Martin N, Loewen R, Borland R, Hyland A, Thompson ME, Boudreau C, Kasza K, Ouimet J, Quah ACK, OConnor RJ, Fong GT (2020) The association of E-cigarette flavors with satisfaction, enjoyment, and trying to quit or stay abstinent from smoking among regular adult vapers from Canada and the United States: findings from the 2018 ITC four country smoking and vaping survey

Additionally, monoamine oxidase inhibitors present in e-liquids, such as vanillin and ethylvanillin, have been proven to enhance nicotine addiction in smokers by delaying the catalytic degradation of monoamine oxidase enzymes to neurotransmitters [46]