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US patent 20070154614 Prachayasittikul S, Wongsawatkul O, Worachartcheewan A, Ruchirawat S, Prachayasittikul V (2010) Vasorelaxation and superoxide scavenging activities of orotic acid

In mouse models of melanoma, colorectal and prostate cancer metastasis, they recorded increased cancer metastases to the lunga common site of cancer metastasisin animals that received tail vein injections of cancer cells preconditioned with PG/VG alone or combined with nicotine as compared to injected cancer cells without preconditioning treatments

Such full-length figures date to the 1700's, but had their heyday in the mid-to late 1800's

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