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After multiple doses, mean IGF-1 levels remained above baseline for up to 28 days, with no serious adverse reactions reported establishing the GHRH-analogue backbone as capable of sustained, clinically meaningful GH and IGF-1 axis elevation

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3 Tirzepatide, the active ingredient in both medications, helps control blood sugar and signals fullness

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With the accumulation of trial and real-world data, these analyses are becoming increasingly feasible

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The combined activity appears to produce greater average weight loss than GLP-1 agonism alone in clinical trials

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