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Power calculations showed that to have 80% power to analyze the association between tobacco use and HPV infection with minimum effect size 0.5%, type I error 5% and the proportion of positive HPV in tobacco users was assumed 4%, and the ratio of non-users and users was 20, thus a minimum 11884 tobacco users and 237678 non-users were required

In regard to the random effects, we include: 1) a random walk term to capture the long-term direction of the trend

California has the highest tax rate of 13.30% for person's married filing jointly making $1,198,024

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