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Diagnostic tools for hematochezia may necessitate lower gastrointestinal tract procedures, such as a colonoscopy and digital rectal exam

Withdrawal symptoms typically begin within 12-24 hours after the last dose, peak in intensity during the first few days, and subside within 7-10 days

While a fibrotic matrix initially contributes to tissue repair, after injury, chronic and persistent kidney damage in the development of CKD leads to uncontrolled fibrotic matrix deposition, resulting in reduced blood supply, destruction of normal organ structure, and eventual glomerulosclerosis, renal tubular atrophy, and interstitial fibrosis [9, 10]

Keap1 responds to oxidative stress signals or chemical inducers by freeing Nrf2