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The binding of the RGD motifs to the V integrins expressed in tumor endothelial cells induces the protease-mediated cleavage of the iRGD peptide, producing two peptides, namely, CRGDR/K and GPDC

As a result, DJX-A-KM continued to suppress cell survival via its intrinsic inhibition even when an sgRNA disrupted the relevant E3 ligase

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