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Some saponins also modulate calcium handling and have anti-apoptotic effects in cardiomyocytes (through PI3K/Akt and other pathways) (Ghafouri-Fard et al., 2022)

Unless smaller companies are acquired or find bigger partners, they may struggle with the cost of making their medicines and getting them to users

This approach is being explored by Amgen with Maridebart cafraglutide (formerly AMG 133) which is formed by two GLP-1 agonist peptides conjugated to an anti-GIP antibody backbone (79)