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Chronic adolescent exposure to 9-tetrahydrocannabinol decreases NMDA current and extrasynaptic plasmalemmal density of NMDA GluN1 subunits in the prelimbic cortex of adult male mice

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Furthermore, acetylcholine-induced production of bioavailable nitric oxide was lower in aortic rings from GPx1 / ApoE mice than ApoE / mice, and the double knockout mice had increased 3-nitrotyrosine staining in atheromatous plaques, similar to earlier findings of endothelial dysfunction in GPx1-deficient mice [39, 70, 71]