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Knippenberg S, Thau N, Dengler R, et al

GIP signaling is commonly linked to broader incretin-based metabolic effects that influence nutrient handling and insulin response

Naltrexone/Bupropion : Offers modest weight loss (56%) but is less effective for PCOS-specific symptoms

The weight-loss drugs, which include Wegovy (semaglutide) and Zepbound (tirzepatide), have become more accessible than ever thanks to recent price cuts, expanding Medicare and Medicaid access, and (more controversially) compounded options from online pharmacies and health startups