While nicotine is not a carcinogen by itself, it is habit-forming, addictive, and is responsible for keeping people hooked, increasing their cigarette consumption exponentially with time
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That has been true from the beginning, when he gained his first huge success as unrepentant cad Alfie, through to the preoperative transsexual killer in Dressed to Kill, slimy underworld king Mortwell in Mona Lisa, the put-out-to-pasture middle-aged businessman who resorts to murder in A Shock to the System and the sadistic, Torquemada-like psychiatrist in the upcoming Quills. There are certain actors (Christopher Walken, for instance, or Harvey Keitel) whom we expect to play villains
By comparison, a meta-analysis (a study combining results several studies at once) of nicotine replacement therapy more generally showed that 22% of those receiving treatment were smoking abstinent at 6-month follow-up