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Naturally, this evolved to make us do things like eat

Lifestyle changes These drinking plenty of water and other liquids eating more fiber-rich foods getting regular exercise Medications Medications for constipation fiber supplements such as Citrucel, FiberCon, or Metamucil stool softeners such as Colace and Docusate prescription medications such as lubiprostone, which increases fluid in your digestive tract The benefits start within a few minutes and increase over time

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Further evidence has shown that disruption of the mechanisms responsible for maintaining the antithrombotic and anti-inflammatory properties of the cerebral microvascular endothelium lead to an increased risk of ischemic stroke (Iadecola and Anrather 2011)