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The final distribution was 39% patients who smoked cannabis and tobacco, 52% patients who smoked only tobacco, and 9% patients who did not smoke (Pradre et al., 2026)

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In the non-psychiatric cohort, CHANTIX was not associated with an increased incidence of clinically significant neuropsychiatric adverse events in a composite endpoint comprising anxiety, depression, feeling abnormal, hostility, agitation, aggression, delusions, hallucinations, homicidal ideation, mania, panic, and irritability