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According to the researchers, their findings broadly suggest that small-molecule GLP-1s could have applications in dysregulating reward signaling, creating implications for the drugs treatment of substance-use disorder and binge-eating

Whether glucagon counter-regulation to hypoglycemia is affected during DPP-4 inhibition in type 2 diabetes has been studied in drug-nave subjects (138), in subjects when a DPP-4 inhibition was added on to insulin therapy (139), and in elderly subjects with metformin-treated type 2 diabetes (140)

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thus, the ratio of SAM/SAH would be altered consistently with NTDs [84]