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Dull needles from repeated use or poor manufacturing require more pressure to penetrate skin, dragging across tissue and amplifying discomfort

The findings indicate broad tissue repair capabilities rather than effects limited to specific anatomical regions

DOSAGE Standard clinical dosing for DSIP has not been established

Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)