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doi:10.1016/j.biochi.2012.10.008 Prasath GS, Subramanian SP (2013) Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats

In contrast, an imbalance between the ratio of ROS and antioxidants adversely downregulates the syncytiotrophoblast due to increased apoptosis (37, 52)

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This is rare in developed countries but can occur in individuals with poor nutrition, substance abuse disorders, or chronic illnesses