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In contrast, we hypothesize that cigarette smoking is increasing the risk of infection and worse disease outcomes (including higher mortality and prolonged disease) mediated by an exacerbation of innate and adaptive inflammatory responses

Mancuso addressed the mechanism behind that moderation directly on Q1 2026 earnings call: I would say the overall OCI was driven primarily through pricing and the stronger cigarette volume performance that you saw play out through the year

The US EPA has now decided not to use the Berman and Crump modeling in risk assessment

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