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Environ Sci Technol 48 , 1275012759 (2014)

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The difficulty of quitting, or kicking the habit, is determined by a few factors, but largely: The drug's interaction with the dopamine receptors The severity of withdrawal symptoms Cognitive changes caused by the drug Physical damage (such as gastrointestinal distress) caused by the drug Psychological addiction Cravings These factors can be measured, and fairly easily used to determine how difficult it will be to quit a drug