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As mentioned, a secondary analysis of an RCT assessing the cardiometabolic effects of exenatide in 40 people with schizophrenia 140 also looked at measures of cognition and psychosocial functioning (that is, Brief Assessment of Cognition in Schizophrenia, ReyOsterreith Complex Figure Test, Short-Form Health Survey, Personal and Social Performance Scale, Positive and Negative Syndrome Scale), but found no effect for this GLP-1RA compared with placebo over 3 months 133

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(Randomized and placebo-controlled means the study looks at two groups of participants who were randomly placed in a group that gets the test treatment or a group that gets the placebo treatment

doi: 10.1046/j.1440-1746.2003.03156.x