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A clinician should review the full medication list, pregnancy plans, gastrointestinal disease history, and prior pancreatitis or gallbladder issues

In their study, four severely obese patients diagnosed with pathogenic heterozygous MC4R variants (2 adults and 2 adolescents) achieved a mean weight reduction of 5.9 kg following 16 weeks of liraglutide treatment, corresponding to a 5.8% reduction from their baseline body weight

SGLT-2 inhibitors, such as empagliflozin, canagliflozin and dapagliflozin, are considered to have intermediate efficacy for glycemic control, and are associated with weight loss and a low risk of hypoglycemia [6]