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COVID-19-brain lysates from aged patients showed increased tau phosphorylation at S199, S202, S214, S262, and S356

This state of hyperinsulinemia and hyperglycemia creates a toxic environment that damages blood vessels, fuels systemic inflammation, and deprives tissues of the energy they need to function, leading to profound fatigue and metabolic instability

In I/R models, lactate released by the kidney enters the liver through portal vein, where it activates pyruvate carboxylase (PC) and phosphoenolpyruvate carboxykinase (PEPCK), thereby promoting glucose synthesis (Yu et al., 2021)

However, In Colombia only some determinations have taken place in small groups (data without publishing), and there exist small work groups from certain universities like the Universidad del Rosario of Bogotas, who will soon give their results in relation to the prevalence of this alteration in the metabolism of hereditary type