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reduces antibody production by decreasing T follicular helper cell (Tfh) to secrete IL-21 and downregulating CXC motif chemokine ligand 13 (CXCL13) expression ( 3 interacts with the gut microbiome, indirectly influencing adaptive immune function through modulation of microbial composition and metabolite production, adding another layer of complexity to its immunoregulatory repertoire ( 3 also contributes to the establishment of central tolerance in the thymus