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We dont want you getting anxious if you stop these medications, she encourages

In the SELECT trial (among others), it showed lower rates of major adverse cardiovascular events (such as heart attacks and strokes) compared to placebo, especially in overweight or obese patients

However, its important to ensure your hypothyroidism is properly treated with appropriate thyroid hormone replacement first, as medication alone cannot fully compensate for untreated hypothyroidism

This guide breaks down the pharmacology, the mechanistic contrast, the head-to-head trial evidence (including the 2025 SURMOUNT-5 results), what enthusiast and research communities online are saying, and the practical realities of sourcing both compounds in Canada