This inconsistency underscores the importance of managing expectations and consulting professionals before beginning supplementation
Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy
Effect of exosomal miRNA on cancer biology and clinical applications
Thus, a potential mechanism underlying paclitaxel-induced chemobrain is the overactivation of intrasynaptic functions ( Similarly, paclitaxel affects synaptic plasticity by increasing presynaptic NMDA receptor (NMDAR) activity, especially that of GluN2A-containing subunits, in the spinal cord, thereby mediating neuropathic pain ( 6 Activation of neuronal apoptosis Apoptosis, also known as programmed cell death, is a tightly regulated physiological process that is essential for maintaining cellular homeostasis by eliminating damaged, dysfunctional, or excess cells without triggering inflammation ( Although paclitaxel is known to induce apoptosis, recent research has highlighted the role of necroptosis, a form of programmed necrotic cell death, in chemobrain ( Paclitaxel can also disrupt intracellular calcium homeostasis by enhancing the interaction between the neuronal calcium sensor-1 protein and inositol-1,4,5-trisphosphate receptor, leading to calcium overload and triggering neuronal cell death pathways, including calpain and caspase 3/7
