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Interestingly, like BETP, compound 2 interacts with cysteine 347 6.36 via covalent modification at the cytoplasmic side of GLP-1R, consistent with our previous observation that an intact extracellular domain (ECD) is required for the activity of BETP and compound 2 34 albeit the basis for such a requirement remains unknown

Instead of white-knuckling diets, patients report fewer cravings, smaller portions, and more energy

acylation to extend half-life, modifications to improve receptor selectivity or bias, PEGylation) are used to improve pharmacokinetics, dosing interval, and tolerability

According to FDA prescribing information, tirzepatide can be administered at any time of day, with or without meals, as its extended half-life maintains stable therapeutic levels regardless of injection time