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Small intestinal glucose exposure determines the magnitude of the incretin effect in health and type 2 diabetes

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Metabolite pathway sets were downloaded from the Small Molecule Pathway Database (SMPDB) (71), and metabolite set enrichment was tested using the limma ROAST method (72)

Thus, the present study provides clear evidence that, at least in Nile tilapia, dietary l-carnitine is physiologically utilised in the transport of acyl-carnitine into mitochondria and improves FA utilisation, while dietary d-carnitine appears to be treated as a xenobiotic and disrupts metabolism