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Cochranes living systematic review has also found evidence that nicotine e-cigarettes can help people stop smoking, while noting that longer-term safety and newer products still require continued evidence review (Lindson et al., 2025

Hormonal Imbalance: Smoking has been linked to hormonal imbalances, including an increase in androgens (male hormones) and a decrease in estrogen (female hormone)

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The initial effort, led by David Amos, was meant to gain more leverage for farmers against the American Tobacco Trust, to reclaim some economic control over their lives