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The combination of nicotine addiction and the cravings for other addictive substances can create a complex interplay that increases the likelihood of relapse

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Overall, study participants diagnosed with ADHD had a one-and-a-half-times greater risk of developing substance abuse than did control participants. While previous studies from Harvard investigators at MGH and elsewhere found an increased risk of substance abuse in adolescents and young adults with ADHD, questions have been raised about whether specific aspects of ADHD such as impulsive behavior, cognitive problems, school problems, accompanying conditions such as bipolar disorder or conduct disorder, or family factors were actually responsible for the risk