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Because amylin receptors are obligate heterodimers of the calcitonin receptor with RAMP1, RAMP2 or RAMP3, the system is a standard model for studying how accessory proteins reshape the ligand binding pocket of a class B1 GPCR, and cagrilintide is used to probe that question alongside selective agonists

E.RaqeebA.Della CorteA.CinelliM.MontagnaniS.et al (2013)

Ein typisches Beispiel: Ein Sportler mit chronischem Reizdarm und gleichzeitiger Sehnenentzndung

It was engineered specifically to target hair follicle stimulation and was first studied in that context in 2007 by researchers at Seoul National University [1]