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What the Published Data Shows Across the research literature, B12 deficiency rates after bariatric surgery fall in the following ranges (3): Roux-en-Y gastric bypass: approximately 2% to 80%, depending on follow-up duration and supplementation Sleeve gastrectomy: 0% to 36.4%, with deficiency often emerging up to two years post-surgery Biliopancreatic diversion with duodenal switch: highest rates, often requiring lifelong parenteral supplementation Weight loss medications: up to 2.6% incidence within one year of treatment These are wide ranges because research has pooled studies with very different follow-up windows and supplementation regimens

(2009) 296:C125870

Overall, five studies were defined as high quality (Reference Hassan, Alalfy and Hassan18,Reference Badawy, El Nashar and El Totongy20,Reference El Sharkwy and Abd El Aziz24,Reference Kose and Naziroglu26,Reference Ghomian, Khadem and Moeindarbari5)

Black arrows indicate caspase-3positive myofibers/cells