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PMCID: PMC9388170
In fact, the use of GSTP1 knockout mice demonstrated that loss of GSTP1 expression increases sensitivity to metabolic or environmental toxins and promotes mutations and cancer development ( FIGURE 2 Prostate cancer Promoter hypermethylation leading to epigenetic silencing of GSTP1 gene expression is frequently detected in prostate cancer cells, the most commonly diagnosed type of malignancy among men in Western European countries and the second cause of cancer-related deaths among men worldwide (Yang and Park, 2012
Similarly, ESPEN recommends a moderate sodium intake of around 60 mmol/day (approximately 1.4 g/day) in patients with ascites but emphasizes that such restriction must not come at the expense of adequate caloric and protein intake [11]
10.1111/j.1432-2277.2005.00185.x 117 RombautM.BoeckmansJ.RodriguesR
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