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Melatonin effectively alleviates nociplastic pain and associated behavioral disturbances by modulating glutamatergic-related synaptic markers in the DRG, restoring mitochondrial function, and reducing microglial activation in the spinal cord

Blood glucose monitoring is essential for patients with diabetes, as tirzepatide may necessitate adjustments to other diabetes medications, particularly insulin or sulfonylureas, to prevent hypoglycemia

SURMOUNT-OSA Study 2 SURMOUNT-OSA study 2 evaluated tirzepatide in adults with moderate-to-severe OSA and obesity who were on and planned to continue to use PAP therapy for 52 weeks

Doria A, Galecki AT, Spino C et al (2020) Serum urate lowering with allopurinol and kidney function in type 1 diabetes