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In a 6-month clinical trial, people who weighed 200 pounds (on average) lost: ~5 lbs on 7 mg of Rybelsus ~7 lbs on 14 mg of Rybelsus Oral semaglutide results for heart health Although a clinical trial suggested oral semaglutide may benefit heart health, Rybelsus is not FDA-approved for this use

The only differences are the indications each is approved for, not the medication itself

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