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This striking evidence gap underscores the need for mechanistic and controlled clinical studies to clarify whether semaglutide uniquely affects salivary secretion

Indeed, novel human studies report that H-1 receptor antagonists inhibit alpha 7nAChRs which turn off the POMC/CART anorexigenic system (139)

12,13 While certain genetic disorders (eg, Kallmann syndrome) are linked to impaired function of the hypothalamus or pituitary gland from birth, toxic exposures and other environmental factors, both in utero and later in life, are also known to interfere with the activities of the gonadotropic hormones