glp-1 ncbi GLP-1/GLP-1R axis: from metabolism (obesity and T2DM) to immunity Designing GLP-1 delivery: structural perspectives

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Kong J, Zhang Z, Musch MW et al (2008) Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier

That finding, combined with mechanistic studies suggesting GLP-1 agonists play a role in brain inflammation, metabolism, and vascular health, is what motivated the Alzheimer's Association to pair the drug class with its proven lifestyle intervention platform

This argument is plausible it reflects a well-documented problem in drug development where unpatentable compounds struggle to attract industry funding regardless of their scientific merit but it should be noted that this explanation, while widely discussed, has not been formally established in the published literature as the primary reason for the evidence gap