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Chronic exposure to this smoke causes metaplastic alterations to the respiratory mucosa with an increase in the number and size of goblet cells and consequent increase in upper airway secretion.17,18 Cohen et al.13 and Kreindler et al.19 also showed in vitro that exposure to cigarette smoke inhibits chloride transport in epithelial cells, causing physiological alterations similar to those found in patients with cystic fibrosis

The environmental impacts of cigarette smoking, from cradle to grave, add significant pressures to the planets increasingly scarce resources and fragile ecosystems," said Professor Nick Voulvoulis, from the Centre for Environmental Policy at Imperial College, who co-authored the report

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Other documents showed that the company conducted research to identify chemicals that could enhance the smell and taste that were similar to those in full-strength cigarettes