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2018;31(3):e12589

Following administration of phenobarbital via drinking water to F344 rats for three weeks, increased liver weight was found to be a result of hepatocellular hypertrophy, hyperplasia, and enlargement of the hepatic blood space (Massey and Butler 1979)

325 At the cellular level this overexcitation stems from a slow synchronous depolarisation of neurones, known as paroxysmal depolarisation shift (PDS) within the epileptic foci

SS-31s effects on muscle tissue make it particularly relevant for active patients and athletes: Improved lactate clearance: mitochondrial efficiency affects how quickly lactate accumulates during high-intensity exercise and how quickly it is cleared during recovery Reduced exercise-induced oxidative stress: the oxidative stress generated by intense exercise is substantially mitochondrial in origin