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A follow-up study confirmed that individuals with inherently higher calories consumed to reach satiation (CTS), that is impaired satiation, prior to treatment displayed greater weight loss in response to phentermine-topiramate

Hepatic lipid content and homeostasis are determined by: (a) circulating free fatty acid uptake, (b) hepatic de novo lipogenesis, (c) hepatic -oxidation, and (d) hepatic lipid export via very-low-density lipoprotein (VLDL) 41,42

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