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ALDEN, an algorithm for assessment of drug causality in Stevens-Johnson Syndrome and toxic epidermal necrolysis: comparison with case-control analysis

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Finally, a rescue experiment was employed to clarify the relationship between FTO and its specific target gene SLC7A11

Meanwhile, the expression of iron metabolism-associated genes, including TRFC, FTH1, and FTL, can be modulated by the epigenetic silencing of the iron-responsive element binding protein 2 (IREB2) (Dixon et al., 2012), while other perturbations of mechanisms, including acetylation and methylation, have been observed to regulate iron metabolism in cancer cells by controlling transcript encoding proteins (Manz et al., 2016)